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Most weight loss pills work by boosting your metabolism with caffeine and other stimulants that are vasoconstrictors - which will raise your BP even more. However, it depends on what type of weight loss pill it is. You said prescription pills, right?? If it's the kind that binds fat and has you excrete it, then it should be okay - but then again if it's prescribed by the doctor then hopefully they know what they are doing. After all, losing weight can help lower your BP in the long run.